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Human recombinant protein FKBP1B
Human Recombinant FKBP1B
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P68106 |
|---|---|
| Concentration | 0.25 |
| Calculated MW | 14.2 kDa |
| Gene ID | 2281 |
|---|---|
| Gene Symbol | FKBP1B |
| Other Names | Peptidyl-prolyl cis-trans isomerase FKBP1B, FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase |
| Gene Source | Human |
| Source | E. Coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Sequence | MGSSHHHHHH SSGLVPRGSH RSMGVEIETI SPGDGRTFPK KGQTCVVHYT GMLQNGKKFD SSRDRNKPFK FRIGKQEVIK GFEEGAAQMS LGQRAKLTCT PDVAYGATGH PGVIPPNATL IFDVELLNLE |
| Format | Liquid |
| Storage | -80°C; 0.25 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 20% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B) belongs to the immunophilin protein family which has a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP1B is a cis-trans prolyl isomerase which binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus). FKBP1B is extremely similar to the FK506-binding protein 1A. The physiological role of FKBP1B is thought to be in excitation-contraction coupling in cardiac muscle.
References
Arakawa H.,et al.Biochem. Biophys. Res. Commun. 200:836-843(1994).
Lam E.,et al.J. Biol. Chem. 270:26511-26522(1995).
Seidler T.,et al.Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
Nakazawa T.,et al.Gene 360:55-64(2005).
Hillier L.W.,et al.Nature 434:724-731(2005).
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