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Haptoglobin, Human Plasma (Mixed Type) recombinant protein
Haptoglobin b-Chain, haptoglobin a-chain; Hp; Bp
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P00738 |
|---|---|
| Calculated MW | Hp 1-1: 86 kDa; Hp 2-1: 200 kDa; Hp 2-2: 400 kDa |
| Gene ID | 3240 |
|---|---|
| Gene Symbol | HP |
| Other Names | Haptoglobin b-Chain, haptoglobin a-chain; Hp; Bp |
| Gene Source | Human |
| Source | Human Plasma |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | N/A; |
| Recombinant | No |
| Target/Specificity | Haptoglobin |
| Format | Lyophilized |
| Storage | -20°C; Lyophilized as a salt-free solid. |
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Provided below are standard protocols that you may find useful for product applications.
Background
An acute-phase plasma protein found in human plasma at 100-300 mg per 100 ml. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes: Hp 1-1, Hp 2-1, and Hp 2-2. While the phenotypic distribution can vary greatly between ethnicities and geographic location, the Hp 2-1 phenotype is the most prevalent phenotype in humans. Plasma concentrations of haptoglobin are highest in individuals with Hp 1-1, intermediate in Hp 2-1 individuals, and lowest in Hp 2-2 individuals. Hp 1-1 is the most effective at binding hemoglobin, and Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype.
References
van der Straten A.,et al.EMBO J. 2:1003-1007(1983).
Yang F.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:5875-5879(1983).
van der Straten A.,et al.FEBS Lett. 168:103-107(1984).
Brune J.L.,et al.Nucleic Acids Res. 12:4531-4538(1984).
Bensi G.,et al.EMBO J. 4:119-126(1985).
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