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CTNND2 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9UQB3
Clone Names 90121088
Peptide ID 90121088
Additional Information
Gene ID 1501
Other Names Catenin delta-2, Delta-catenin, GT24, Neural plakophilin-related ARM-repeat protein, NPRAP, Neurojungin, CTNND2, NPRAP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NPRAP
Function Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta- catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.
Cellular Location Nucleus {ECO:0000250|UniProtKB:O35927}. Cell junction, adherens junction {ECO:0000250|UniProtKB:O35927}. Cell projection, dendrite {ECO:0000250|UniProtKB:O35116}. Perikaryon
Tissue Location Expressed in brain; highest expression is observed in fetal brain (PubMed:25807484)
Research Areas
Citations (0)

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This gene encodes an adhesive junction associated proteinof the armadillo/beta-catenin superfamily and is implicated inbrain and eye development and cancer formation. The protein encodedby this gene promotes the disruption of E-cadherin based adherensjunction to favor cell spreading upon stimulation by hepatocytegrowth factor. This gene is overexpressed in prostateadenocarcinomas and is associated with decreased expression oftumor suppressor E-cadherin in this tissue. This gene resides in aregion of the short arm of chromosome 5 that is deleted in Cri duChat syndrome.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Zhang, J., et al. Exp. Cell Res. 316(6):1070-1081(2010)Yang, I., et al. Mol. Cells 29(3):233-237(2010)Stenzel, N., et al. J. Cell. Sci. 122 (PT 18), 3374-3384 (2009) :Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)

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Cat# BP12548b
Availability: Back Order
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