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CTNND2 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CTNND2 Antibody (C-term) AP12548b
    CTNND2 Antibody (C-term) (Cat. #AP12548b) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the CTNND2 antibody detected the CTNND2 protein (arrow).
    detail
  • WB - CTNND2 Antibody (C-term) AP12548b
    CTNND2 Antibody (C-term) (Cat. #AP12548b) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the CTNND2 antibody detected the CTNND2 protein (arrow).
    detail
  • IHC-P - CTNND2 Antibody (C-term) AP12548b
    CTNND2 Antibody (C-term) (Cat. #AP12548b)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CTNND2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q9UQB3
Other Accession O35927, NP_001323.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 132656 Da
Antigen Region 1131-1159 aa
Additional Information
Gene ID 1501
Other Names Catenin delta-2, Delta-catenin, GT24, Neural plakophilin-related ARM-repeat protein, NPRAP, Neurojungin, CTNND2, NPRAP
Target/Specificity This CTNND2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1131-1159 amino acids from the C-terminal region of human CTNND2.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCTNND2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CTNND2
Synonyms NPRAP
Function Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.
Cellular Location Nucleus {ECO:0000250|UniProtKB:O35927}. Cell junction, adherens junction {ECO:0000250|UniProtKB:O35927}. Cell projection, dendrite {ECO:0000250|UniProtKB:O35116}. Perikaryon
Tissue Location Expressed in brain; highest expression is observed in fetal brain (PubMed:25807484).
Research Areas
Citations (0)
citation

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Background

This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Zhang, J., et al. Exp. Cell Res. 316(6):1070-1081(2010)
Yang, I., et al. Mol. Cells 29(3):233-237(2010)
Stenzel, N., et al. J. Cell. Sci. 122 (PT 18), 3374-3384 (2009) :
Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)

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$ 182.50
$ 70.00
Cat# AP12548b
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