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CTNND2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CTNND2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9UQB3 |
| Other Accession | NM_001332 |
| Reactivity | Human, Rat |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 6E12 |
| Calculated MW | 132656 Da |
| Gene ID | 1501 |
|---|---|
| Other Names | Catenin delta-2, Delta-catenin, GT24, Neural plakophilin-related ARM-repeat protein, NPRAP, Neurojungin, CTNND2, NPRAP |
| Target/Specificity | CTNND2 (NP_001323, 1081 a.a. ~ 1190 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CTNND2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome.
References
1.Identification of Novel NPRAP/?_-Catenin-Interacting Proteins and the Direct Association of NPRAP with Dynamin 2.Koutras C, Levesque G.PLoS One. 2011;6(10):e25379. Epub 2011 Oct 14.
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