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CPT2 (aa141-154) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P23786 |
| Other Accession | NP_000089.1, 1376 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Pig, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 73777 Da |
| Gene ID | 1376 |
|---|---|
| Other Names | Carnitine O-palmitoyltransferase 2, mitochondrial, 2.3.1.21, Carnitine palmitoyltransferase II, CPT II, CPT2, CPT1 |
| Dilution | WB~~1:1000 E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CPT2 (aa141-154) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CPT2 (HGNC:2330) |
|---|---|
| Synonyms | CPT1 |
| Function | Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites (PubMed:20538056, PubMed:24780397). Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8- C12) and long-chain (C14-C18) acyl-CoA esters (PubMed:20538056). |
| Cellular Location | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side |
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Provided below are standard protocols that you may find useful for product applications.
References
CPT2 gene mutations resulting in lethal neonatal or severe infantile carnitine palmitoyltransferase II deficiency. Isackson PJ, Bennett MJ, Lichter-Konecki U, Willis M, Nyhan WL, Sutton VR, Tein I, Vladutiu GD, Molecular genetics and metabolism 2008 Aug 94 (4): 422-7. PMID: 18550408
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