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AES Antibody (N-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q08117 |
| Other Accession | NP_945320.1, NP_001121.2, NP_945321.1, 166, 14797 (mouse), 29466 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 21970 Da |
| Gene ID | 166 |
|---|---|
| Other Names | Amino-terminal enhancer of split, Amino enhancer of split, Gp130-associated protein GAM, Grg-5, Groucho-related protein 5, Protein ESP1, Protein GRG, AES, GRG, GRG5 |
| Dilution | WB~~1:1000 E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AES Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TLE5 (HGNC:307) |
|---|---|
| Synonyms | AES, GRG, GRG5 |
| Function | Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. |
| Cellular Location | Nucleus. |
| Tissue Location | Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize all reported isoforms (NP_945320.1; NP_001121.2; NP_945321.1).
References
Histone deacetylase-related protein inhibits AES-mediated neuronal cell death by direct interaction. Zhang X, Chen HM, Jaramillo E, Wang L, D'Mello SR. J Neurosci Res. 2008 Aug 15;86(11):2423-31. PMID: 18438919
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