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Goat Anti-TIAM1 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
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- BACKGROUND
Application 
| IF, FC, E |
|---|---|
| Primary Accession | Q13009 |
| Other Accession | NP_003244, NP_001340613.1, NP_001340614.1, NP_001340615.1, NP_001340616.1 |
| Reactivity | Human |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 177508 Da |
| Gene ID | 7074 |
|---|---|
| Other Names | T-lymphoma invasion and metastasis-inducing protein 1, TIAM-1, TIAM1 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
| Immunogen | Peptide with sequence C-EDFAPSRKLNTEI, from the C Terminus of the protein sequence according to NP_003244; NP_001340613.1; NP_001340614.1; NP_001340615.1; NP_001340616.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-TIAM1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TIAM1 {ECO:0000303|PubMed:7731688, ECO:0000312|HGNC:HGNC:11805} |
|---|---|
| Function | Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. |
| Cellular Location | Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction |
| Tissue Location | Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 423.00
Cat# AF4326a
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