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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Bcl-XL Rabbit Monoclonal Antibody
KD-Validated Anti-Bcl-XL Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q07817 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 3000 |
| Calculated MW | Predicted, 26 kDa , observed, 26 kDa |
| Gene Name | BCL2L1 |
| Aliases | BCL2L1; BCL2 Like 1; BCL2L; BCLX; PPP1R52; Protein Phosphatase 1, Regulatory Subunit 52; Apoptosis Regulator Bcl-X; Bcl-2-Like Protein 1; Bcl-X; BCL-XL/S; Bcl2-L-1; Bcl-XL; Bcl-XS; BCL-XL; BCL-XS; BCL-X |
| Immunogen | A synthesized peptide derived from human Bcl-XL |
| Gene ID | 598 |
|---|---|
| Other Names | Bcl-2-like protein 1, Bcl2-L-1, Apoptosis regulator Bcl-X, BCL2L1, BCL2L, BCLX |
| Name | BCL2L1 |
|---|---|
| Synonyms | BCL2L, BCLX |
| Function | Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(S) promotes apoptosis. |
| Cellular Location | [Isoform Bcl-X(L)]: Mitochondrion inner membrane. Mitochondrion outer membrane Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49 |
| Tissue Location | Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 149.00
$ 499.00
Cat# AGI1163
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