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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-NHERF1 Rabbit Monoclonal Antibody
KD-Validated Anti-NHERF1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
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- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC |
|---|---|
| Primary Accession | O14745 |
| Reactivity | Rat, Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB1270 |
| Calculated MW | Predicted, 39 kDa , o bserved , 50 kDa |
| Gene Name | NHERF1 |
| Aliases | NHERF1; NHERF Family PDZ Scaffold Protein 1; NHERF-1; NHERF; EBP50; SLC9A3R1; NHE-RF; Solute Carrier Family 9, Subfamily A (NHE3, Cation Proton Antiporter 3), Member 3 Regulator 1; Na(+)/H(+) Exchange Regulatory Cofactor NHE-RF1; Ezrin-Radixin-Moesin-Binding Phosphoprotein 50; Regulatory Cofactor Of Na(+)/H(+) Exchanger; Na(+)/H(+) Exchange Regulatory Cofactor 1; SLC9A3 Regulator 1; Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 3 Regulatory Factor 1; Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 3 Regulator 1; Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 3 Regulator 1; Solute Carrier Family 9 Isoform A3 Regulatory Factor 1; Ezrin-Radixin-Moesin Binding Phosphoprotein-50; Sodium-Hydrogen Exchanger Regulatory Factor 1; Na+/H+ Exchange Regulatory Co-Factor; NPHLOP2 |
| Immunogen | A synthesized peptide derived from human EBP50 |
| Gene ID | 9368 |
|---|---|
| Other Names | Na(+)/H(+) exchange regulatory cofactor NHE-RF1, NHERF-1, Ezrin-radixin-moesin-binding phosphoprotein 50, EBP50, Regulatory cofactor of Na(+)/H(+) exchanger, Sodium-hydrogen exchanger regulatory factor 1, Solute carrier family 9 isoform A3 regulatory factor 1, NHERF1 (HGNC:11075), NHERF, SLC9A3R1 |
| Name | NHERF1 (HGNC:11075) |
|---|---|
| Synonyms | NHERF, SLC9A3R1 |
| Function | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. |
| Cellular Location | Cytoplasm. Apical cell membrane. Endomembrane system; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Note=Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Found in microvilli, ruffling membrane and filopodia of HeLa cells. Present in lipid rafts of T-cells. |
| Tissue Location | Detected in liver, kidney, pancreas, prostate, spleen, small intestine and placenta, in particular in the syncytiotrophoblast. |
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$ 149.00
$ 499.00
Cat# AGI1669
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