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KD-Validated Anti-BCL2 Like 1 Rabbit Monoclonal Antibody

Rabbit monoclonal antibody

     
  • WB - KD-Validated Anti-BCL2 Like 1 Rabbit Monoclonal Antibody AGI1882
    Western blotting analysis using anti-BCL2 like 1 antibody (Cat#63370). Total cell lysates (30 µg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-BCL2 like 1 antibody (Cat#63370, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716).
    detail
  • WB - KD-Validated Anti-BCL2 Like 1 Rabbit Monoclonal Antibody AGI1882
    Western blotting analysis using anti-BCL2 like 1 antibody (Cat#63370). BCL2 like 1 expression in wild type (WT) and BCL2 like 1 (BCL2L1) shRNA knockdown (KD) HeLa cells with 20 µg of total cell lysates. β-Tubulin serves as a loading control. The blot was incubated with anti-BCL2 like 1 antibody (Cat#63370, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using NaQ™ ECL Substrate Kit (Cat#716).
    detail
  • ICC - KD-Validated Anti-BCL2 Like 1 Rabbit Monoclonal Antibody AGI1882
    Immunocytochemical staining of HT-1080 cells with anti-BCL2 like 1 antibody(Cat#63370, 1:1,000). Nuclei were stained blue with DAPI; BCL2 like 1 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar, 20 µm.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, ICC
Primary Accession Q07817
Reactivity Rat, Human, Mouse
Clonality Monoclonal
Isotype Rabbit IgG
Clone Names 24GB5350
Calculated MW Predicted, 26 kDa, observed, 30 kDa
Gene Name BCL2L1
Aliases BCL2L1; BCL2 Like 1; BCL2L; BCLX; PPP1R52; Bcl-X; Protein Phosphatase 1, Regulatory Subunit 52; Apoptosis Regulator Bcl-X; Bcl-2-Like Protein 1; Bcl-XL; Bcl-XS; BCL-XL/S; Bcl2-L-1
Immunogen Recombinant protein of human Bcl-XL
Additional Information
Gene ID 598
Other Names Bcl-2-like protein 1, Bcl2-L-1, Apoptosis regulator Bcl-X, BCL2L1, BCL2L, BCLX
Protein Information
Name BCL2L1
Synonyms BCL2L, BCLX
Function Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(S) promotes apoptosis.
Cellular Location [Isoform Bcl-X(L)]: Mitochondrion inner membrane. Mitochondrion outer membrane Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49
Tissue Location Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1882
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