KD-Validated Anti-ACACA Rabbit Polyclonal Antibody
Rabbit polyclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB |
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Primary Accession | Q13085 |
Reactivity | Rat, Human, Mouse |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | Predicted, 266 kDa, observed, 250 kDa |
Gene Name | ACACA |
Aliases | ACACA; Acetyl-CoA Carboxylase Alpha; ACC-Alpha; ACC1; ACCA; Acetyl-Coenzyme A Carboxylase Alpha; Acetyl-CoA Carboxylase 1; ACACalpha; ACCalpha; Acac1; HACC1; ACAC; ACC; EC 6.4.1.2; ACACAD |
Immunogen | A synthesized peptide derived from human ACC alpha |
Gene ID | 31 |
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Other Names | Acetyl-CoA carboxylase 1, ACC1, 6.4.1.2, Acetyl-Coenzyme A carboxylase alpha, ACC-alpha, ACACA (HGNC:84), ACAC, ACC1, ACCA |
Name | ACACA (HGNC:84) |
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Synonyms | ACAC, ACC1, ACCA |
Function | Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443). |
Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5SWU9} |
Tissue Location | Expressed in brain, placenta, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver |

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