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GPR68 / OGR1 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q15743 |
| Reactivity | Human, Mouse, Rabbit, Hamster, Monkey, Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 41kDa |
| Dilution | IHC-P (10-20 µg/ml) |
| Gene ID | 8111 |
|---|---|
| Other Names | Ovarian cancer G-protein coupled receptor 1, OGR-1, G-protein coupled receptor 68, GPR12A, Sphingosylphosphorylcholine receptor, GPR68, OGR1 |
| Target/Specificity | Human GPR68. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | GPR68 / OGR1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR68 |
|---|---|
| Synonyms | OGR1 |
| Function | Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity).
References
An S.,et al.FEBS Lett. 375:121-124(1995).
Xu Y.,et al.Genomics 35:397-402(1996).
Kaighin V.A.,et al.Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
King M.M.,et al.Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
Heilig R.,et al.Nature 421:601-607(2003).
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