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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > BOB / GPR15 Antibody (Extracellular Domain)
BOB / GPR15 Antibody (Extracellular Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P49685 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 41kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 2838 |
|---|---|
| Other Names | G-protein coupled receptor 15, Brother of Bonzo, BoB, GPR15 |
| Target/Specificity | Human GPR15. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | BOB / GPR15 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR15 |
|---|---|
| Function | G protein-coupled receptor that plays an important role in immune homeostasis (PubMed:33758080, PubMed:38918398). Acts via its natural ligand GPR15LG, a chemokine-like polypeptide strongly expressed in gastrointestinal tissues. GPR15-GPR15LG signaling axis regulates intestinal homeostasis and inflammation through the migration of immune cells (PubMed:33758080, PubMed:38918398). Controls thereby the specific homing of T-cells, particularly FOXP3+ regulatory T-cells (Tregs), to the large intestine lamina propria (By similarity). Also required for skin localization of thymus-derived dendritic epidermal T-cells (By similarity). Plays an important role in mediating cytoprotective function as well as angiogenesis of thrombomodulin (By similarity). Mechanistically, preferentially signals through the Gi/o pathway to inhibit adenylate cyclase activity and activate a phosphatidylinositol- calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed:35510660). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in lymphoid tissues, including macrophages and peripheral blood mononuclear cells |
| Volume | 50 µl |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.
References
Heiber M.,et al.Genomics 32:462-465(1996).
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$ 467.50
Cat# ALS10418
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