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ADGRG3 / GPR97 Antibody (Extracellular Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q86Y34 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61kDa |
| Dilution | IHC-P (15-30 µg/ml) |
| Gene ID | 222487 |
|---|---|
| Other Names | Probable G-protein coupled receptor 97, G-protein coupled receptor PGR26, GPR97, PGR26 |
| Target/Specificity | Human GPR97. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | ADGRG3 / GPR97 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADGRG3 (HGNC:13728) |
|---|---|
| Synonyms | GPR97, PGR26 |
| Function | Adhesion G-protein-coupled receptor (aGPCR) that plays a role in the regulation of various processes including B-cell development, inflammation or innate immunity. Acts upon activation by ligands including glucocorticoid hormones such as cortisol, cortisone and 11- deoxycortisol (PubMed:33408414). Regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Seems to signal through G-alpha(q)-proteins (PubMed:22575658). Provides basal Galphas/cAMP-mediated signal transduction, which has been shown to inhibit NF-kappa-B transcriptional activity. Antibody ligation leads to the production and activation of antimicrobial mediators like reactive oxygen species (ROS) and myeloperoxidase (MPO) as well as enhanced bacteria uptake and killing by granulocytes (PubMed:30559745). Additionally, collaborates with protease-activated receptor 2/PAR2 to stimulate neutrophil-driven antimicrobial responses and endothelial cell activation (PubMed:36302784). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in cultured primary dermal lymphatic endothelial cells (PubMed:24178298). Highly expressed in polymorphonuclear cells (PMNs) including neutrophilic, eosinophilic, and basophilic granulocytes (PubMed:30559745) |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Orphan receptor.
References
Okaze H.,et al.Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
Fredriksson R.,et al.FEBS Lett. 531:407-414(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
Vassilatis D.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
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