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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-GPR97 Antibody
Anti-GPR97 Antibody
Rabbit polyclonal antibody to GPR97
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Application 
| WB, IF/IC |
|---|---|
| Primary Accession | Q86Y34 |
| Other Accession | Q8R0T6 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 60861 Da |
| Gene ID | 222487 |
|---|---|
| Other Names | PGR26; Probable G-protein coupled receptor 97; G-protein coupled receptor PGR26 |
| Target/Specificity | Recognizes endogenous levels of GPR97 protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IF/IC (1/100 - 1/500) IF~~WB (1/500 - 1/1000), IF/IC (1/100 - 1/500) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | ADGRG3 (HGNC:13728) |
|---|---|
| Synonyms | GPR97, PGR26 |
| Function | Adhesion G-protein-coupled receptor (aGPCR) that plays a role in the regulation of various processes including B-cell development, inflammation or innate immunity. Acts upon activation by ligands including glucocorticoid hormones such as cortisol, cortisone and 11- deoxycortisol (PubMed:33408414). Regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42 (PubMed:24178298). Seems to signal through G-alpha(q)-proteins (PubMed:22575658). Provides basal Galphas/cAMP-mediated signal transduction, which has been shown to inhibit NF-kappa-B transcriptional activity. Antibody ligation leads to the production and activation of antimicrobial mediators like reactive oxygen species (ROS) and myeloperoxidase (MPO) as well as enhanced bacteria uptake and killing by granulocytes (PubMed:30559745). Additionally, collaborates with protease-activated receptor 2/PAR2 to stimulate neutrophil-driven antimicrobial responses and endothelial cell activation (PubMed:36302784). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in cultured primary dermal lymphatic endothelial cells (PubMed:24178298). Highly expressed in polymorphonuclear cells (PMNs) including neutrophilic, eosinophilic, and basophilic granulocytes (PubMed:30559745) |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GPR97. The exact sequence is proprietary.
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$ 385.00
$ 195.00
Cat# AP60568
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