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SIK2 / SNF1LK2 Antibody (clone S15G10)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC, IP |
|---|---|
| Primary Accession | Q9H0K1 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | S15G10 |
| Calculated MW | 104kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 23235 |
|---|---|
| Other Names | Serine/threonine-protein kinase SIK2, 2.7.11.1, Qin-induced kinase, Salt-inducible kinase 2, SIK-2, Serine/threonine-protein kinase SNF1-like kinase 2, SIK2 |
| Target/Specificity | Recombinant human SIK2 |
| Reconstitution & Storage | Store at 4°C. Do not freeze. |
| Precautions | SIK2 / SNF1LK2 Antibody (clone S15G10) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SIK2 |
|---|---|
| Synonyms | KIAA0781 {ECO:0000312|EMBL:BAA34501.3}, |
| Function | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). |
| Cellular Location | Cytoplasm. Endoplasmic reticulum membrane |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
References
Lizcano J.M.,et al.EMBO J. 23:833-843(2004).
Nagase T.,et al.DNA Res. 5:277-286(1998).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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