SIK2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9H0K1 |
Other Accession | Q8CFH6, NP_056006.1 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 103915 Da |
Antigen Region | 332-358 aa |
Gene ID | 23235 |
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Other Names | Serine/threonine-protein kinase SIK2, Qin-induced kinase, Salt-inducible kinase 2, SIK-2, Serine/threonine-protein kinase SNF1-like kinase 2, SIK2 |
Target/Specificity | This SIK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-358 amino acids from the Central region of human SIK2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SIK2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SIK2 |
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Synonyms | KIAA0781 {ECO:0000312|EMBL:BAA34501.3}, |
Function | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity). |
Cellular Location | Cytoplasm. Endoplasmic reticulum membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
References
Ahmed, A.A., et al. Cancer Cell 18(2):109-121(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Nagel, S., et al. Leuk. Lymphoma 51(5):881-891(2010)
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
Katoh, Y., et al. Eur. J. Biochem. 271(21):4307-4319(2004)
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