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HMGIY / HMGA1 Antibody
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P17096 |
| Reactivity | Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Horse, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 12kDa |
| Dilution | ELISA (1:16000), IHC-P (3.75 µg/ml), WB (0.5-1 µg/ml) |
| Gene ID | 3159 |
|---|---|
| Other Names | High mobility group protein HMG-I/HMG-Y, HMG-I(Y), High mobility group AT-hook protein 1, High mobility group protein A1, High mobility group protein R, HMGA1, HMGIY |
| Target/Specificity | Human HMGA1. This antibody is expected to recognize reported isoforms a (NP_665906.1, NP_665908.1, NP_665911.1) and b (NP_002122.1, NP_665910.1, NP_665912.1). This antibody is not expected to cross-react with HMGA2. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | HMGIY / HMGA1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HMGA1 |
|---|---|
| Synonyms | HMGIY |
| Function | HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. |
| Cellular Location | Nucleus. Chromosome. |
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Provided below are standard protocols that you may find useful for product applications.
Background
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
References
Eckner R.,et al.Nucleic Acids Res. 17:5947-5959(1989).
Johnson K.R.,et al.Mol. Cell. Biol. 9:2114-2123(1989).
Friedmann M.,et al.Nucleic Acids Res. 21:4259-4267(1993).
Nagpal S.,et al.J. Biol. Chem. 274:22563-22568(1999).
Mungall A.J.,et al.Nature 425:805-811(2003).
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