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OSBPL1A / ORP1 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9BXW6 |
| Reactivity | Human, Mouse, Rat, Monkey, Pig, Chicken, Horse, Bovine, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 108kDa |
| Dilution | ELISA (1:16000), IHC-P (5 µg/ml), WB (0.5-2 µg/ml) |
| Gene ID | 114876 |
|---|---|
| Other Names | Oxysterol-binding protein-related protein 1, ORP-1, OSBP-related protein 1, OSBPL1A, ORP1, OSBP8, OSBPL1, OSBPL1B |
| Target/Specificity | Human OSBPL1A / ORP1. This antibody is expected to recognise both reported human isoforms of this protein. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | OSBPL1A / ORP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OSBPL1A (HGNC:16398) |
|---|---|
| Function | Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). |
| Cellular Location | Late endosome. Note=Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A.
References
Jaworski C.J.,et al.Genomics 78:185-196(2001).
Xu Y.,et al.J. Biol. Chem. 276:18407-18414(2001).
Lehto M.,et al.J. Lipid Res. 42:1203-1213(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 437:551-555(2005).
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