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OSBPL1A Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BXW6 |
| Other Accession | Q8K4M9, Q91XL9, NP_542164.2, NP_060500.3 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 108470 Da |
| Antigen Region | 736-763 aa |
| Gene ID | 114876 |
|---|---|
| Other Names | Oxysterol-binding protein-related protein 1, ORP-1, OSBP-related protein 1, OSBPL1A, ORP1, OSBP8, OSBPL1, OSBPL1B |
| Target/Specificity | This OSBPL1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 736-763 amino acids from the C-terminal region of human OSBPL1A. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OSBPL1A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OSBPL1A (HGNC:16398) |
|---|---|
| Function | Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). |
| Cellular Location | Late endosome. Note=Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Hsu, Y.H., et al. PLoS Genet. 6 (6), E1000977 (2010) :
Rocha, N., et al. J. Cell Biol. 185(7):1209-1225(2009)
Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
Bjornsson, H.T., et al. Genome Res. 18(5):771-779(2008)
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