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PNPLA3 / Adiponutrin Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9NST1 |
| Reactivity | Human, Mouse, Rat, Rabbit, Hamster |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 53kDa |
| Dilution | ELISA (1:128000), IHC-P (3.75 µg/ml), WB (0.05-0.2 µg/ml) |
| Gene ID | 80339 |
|---|---|
| Other Names | Patatin-like phospholipase domain-containing protein 3, 3.1.1.3, Acylglycerol O-acyltransferase, 2.3.1.-, Adiponutrin, Calcium-independent phospholipase A2-epsilon, iPLA2-epsilon, PNPLA3, ADPN, C22orf20 |
| Target/Specificity | Human PNPLA3. This antibody is raised against a peptide derived from the Mouse protein sequence and this peptide differs from Human only in position 2. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | PNPLA3 / Adiponutrin Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLPL3 |
|---|---|
| Function | Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA (PubMed:22560221). Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides (PubMed:15364929, PubMed:20034933, PubMed:22560221). In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety (PubMed:21878620). However, the triacylglycerol hydrolase activity is controversial and may be very low (PubMed:22560221). Possesses phospholipase A2 activity (PubMed:15364929). |
| Cellular Location | Membrane; Single-pass type II membrane protein. Lipid droplet |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities.
References
Collins J.E.,et al.Genome Res. 13:27-36(2003).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham I.,et al.Nature 402:489-495(1999).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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