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ATP6V1A1 / ATP6V1A Antibody (clone 4F5)

Mouse Monoclonal Antibody

     
  • WB - ATP6V1A1 / ATP6V1A Antibody (clone 4F5) ALS14267
    ATP6V1A monoclonal antibody, clone 4F5. Western blot of ATP6V1A expression in human kidney.
    detail
  • IHC - ATP6V1A1 / ATP6V1A Antibody (clone 4F5) ALS14267
    Anti-ATP6V1A antibody IHC of human tonsil.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P38606
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 4F5
Calculated MW 68kDa
Dilution IHC-P (5 µg/ml), WB (1:500-1:1000),
Additional Information
Gene ID 523
Other Names V-type proton ATPase catalytic subunit A, V-ATPase subunit A, 3.6.3.14, V-ATPase 69 kDa subunit, Vacuolar ATPase isoform VA68, Vacuolar proton pump subunit alpha, ATP6V1A, ATP6A1, ATP6V1A1, VPP2
Target/Specificity Human ATP6V1A
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsATP6V1A1 / ATP6V1A Antibody (clone 4F5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATP6V1A
Synonyms ATP6A1, ATP6V1A1, VPP2
Function Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:8463241). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in neurite development and synaptic connectivity (PubMed:29668857).
Cellular Location Cytoplasm. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P50516}. Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P31404}; Peripheral membrane protein. Lysosome {ECO:0000250|UniProtKB:P50516} Note=Co-localizes with WFS1 in the secretory granules in neuroblastoma cell lines.
Tissue Location High expression in the skin.
Research Areas
Citations (0)
citation

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Background

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

References

van Hille B.,et al.J. Biol. Chem. 268:7075-7080(1993).
Hu R.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).

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Discontinued
Cat# ALS14267
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