GPR171 Antibody (aa141-190)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
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Primary Accession | O14626 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 37kDa |
Dilution | ELISA (1:1000), IF (1:100-1:500), IHC-P (5 µg/ml), WB (1:500-1:1000) , |
Gene ID | 29909 |
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Other Names | Probable G-protein coupled receptor 171, G-protein coupled receptor H963, GPR171, H963 |
Target/Specificity | GPR171 Antibody detects endogenous levels of total GPR171 protein. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | GPR171 Antibody (aa141-190) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GPR171 (HGNC:30057) |
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Synonyms | H963 |
Function | G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception (By similarity). Acts as a negative regulator T cell function (PubMed:34615877). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8BG55}; Multi-pass membrane protein. Note=Colocalized with GPR83 in the paraventricular nucleus. {ECO:0000250|UniProtKB:Q8BG55} |
Tissue Location | Expressed in both T-cell subsets and natural killer cells, while it is undetectable in B cells or CD14(+) monocytes Expressed in peripheral blood mononuclear cells (PBMC) and Jurkat cells (at protein level). |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Orphan receptor.
References
Jacobs K.A.,et al.Gene 198:289-296(1997).
Joensuu T.,et al.Am. J. Hum. Genet. 69:673-684(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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