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GPR171 Antibody (aa141-190)

Rabbit Polyclonal Antibody

     
  • IF - GPR171 Antibody (aa141-190) ALS15340
    Immunofluorescence of MCF7 cells, using GPR171 Antibody.
    detail
  • WB - GPR171 Antibody (aa141-190) ALS15340
    Western blot of extracts from K562 cells, using GPR171 Antibody.
    detail
  • IHC - GPR171 Antibody (aa141-190) ALS15340
    Anti-GPR171 antibody IHC of human prostate.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O14626
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 37kDa
Dilution ELISA (1:1000), IF (1:100-1:500), IHC-P (5 µg/ml), WB (1:500-1:1000) ,
Additional Information
Gene ID 29909
Other Names Probable G-protein coupled receptor 171, G-protein coupled receptor H963, GPR171, H963
Target/Specificity GPR171 Antibody detects endogenous levels of total GPR171 protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsGPR171 Antibody (aa141-190) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR171 (HGNC:30057)
Synonyms H963
Function G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception (By similarity). Acts as a negative regulator T cell function (PubMed:34615877).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q8BG55}; Multi-pass membrane protein. Note=Colocalized with GPR83 in the paraventricular nucleus. {ECO:0000250|UniProtKB:Q8BG55}
Tissue Location Expressed in both T-cell subsets and natural killer cells, while it is undetectable in B cells or CD14(+) monocytes Expressed in peripheral blood mononuclear cells (PBMC) and Jurkat cells (at protein level).
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Orphan receptor.

References

Jacobs K.A.,et al.Gene 198:289-296(1997).
Joensuu T.,et al.Am. J. Hum. Genet. 69:673-684(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS15340
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