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CNTN1 / gp135 / Contactin 1 Antibody (aa313-324)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q12860 |
| Reactivity | Human, Mouse, Rat, Monkey, Pig, Guinea Pig |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 113kDa |
| Dilution | ELISA (1:32000), IHC-P (5 µg/ml), WB (0.3-1 µg/ml) |
| Gene ID | 1272 |
|---|---|
| Other Names | Contactin-1, Glycoprotein gp135, Neural cell surface protein F3, CNTN1 |
| Target/Specificity | Human CNTN1 / gp135 / Contactin 1. This antibody is expected to recognize all reported isoforms (NP_001834.2; NP_778203.1; NP_001242992.1). Reported variants represent identical protein: NP_001242993.1, NP_001242992.1. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | CNTN1 / gp135 / Contactin 1 Antibody (aa313-324) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CNTN1 |
|---|---|
| Function | Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity). |
| Cellular Location | [Isoform 1]: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side |
| Tissue Location | Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).
References
Reid R.A.,et al.Brain Res. Mol. Brain Res. 21:1-8(1994).
Berglund E.O.,et al.Genomics 21:571-582(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Berglund E.,et al.Eur. J. Biochem. 197:549-554(1991).
Liu T.,et al.J. Proteome Res. 4:2070-2080(2005).
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