CNTN1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, E |
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Primary Accession | Q12860 |
Other Accession | Q63198, P12960, Q28106 |
Reactivity | Human |
Predicted | Bovine, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 113320 Da |
Antigen Region | 635-662 aa |
Gene ID | 1272 |
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Other Names | Contactin-1, Glycoprotein gp135, Neural cell surface protein F3, CNTN1 |
Target/Specificity | This CNTN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 635-662 amino acids from the Central region of human CNTN1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CNTN1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CNTN1 |
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Function | Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity). |
Cellular Location | [Isoform 1]: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side |
Tissue Location | Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle. |

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Provided below are standard protocols that you may find useful for product applications.
Background
CNTN1 is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system.
References
Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :
Compton, A.G., et al. Am. J. Hum. Genet. 83(6):714-724(2008)
Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008)

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