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C1orf187 / DRAXIN Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q8NBI3 |
| Other Accession | 374946 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 38650 Da |
| Dilution | IF (20 µg/ml), IHC-P (5 µg/ml), WB (1 µg/ml), |
| Gene ID | 374946 |
|---|---|
| Other Names | DRAXIN, AGPA3119, UNQ3119, C1orf187, Neucrin |
| Target/Specificity | Human C1orf187 / Neucrin/ Draxin. At least three isoforms of Neucrin are known to exist; this antibody will detect the two shorter isoforms. Neucrin antibody is predicted to not cross-react with RILP. |
| Reconstitution & Storage | PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | C1orf187 / DRAXIN Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DRAXIN {ECO:0000255|HAMAP-Rule:MF_03060} |
|---|---|
| Synonyms | C1orf187 |
| Function | Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. |
| Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
References
Miyake A.,et al.Biochem. Biophys. Res. Commun. 390:1051-1055(2009).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Otsuki T.,et al.DNA Res. 12:117-126(2005).
Gregory S.G.,et al.Nature 441:315-321(2006).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
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