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Anti-GPR171 Antibody (Extracellular Domain)

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession O14626
Predicted Human, Rabbit, Monkey, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 36754 Da
Dilution IHC-P (10 - 20 µg/ml)
Additional Information
Gene ID 29909
Alias Symbol GPR171
Other Names GPR171, H963, G protein-coupled receptor 171
Target/Specificity Human GPR171. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-GPR171 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR171 (HGNC:30057)
Synonyms H963
Function G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception (By similarity). Acts as a negative regulator T cell function (PubMed:34615877).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q8BG55}; Multi-pass membrane protein. Note=Colocalized with GPR83 in the paraventricular nucleus. {ECO:0000250|UniProtKB:Q8BG55}
Tissue Location Expressed in both T-cell subsets and natural killer cells, while it is undetectable in B cells or CD14(+) monocytes Expressed in peripheral blood mononuclear cells (PBMC) and Jurkat cells (at protein level).
Research Areas
Citations (0)
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$ 467.50
Cat# ALS17671
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