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SMYD1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q8NB12 |
| Other Accession | NP_938015.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56617 Da |
| Antigen Region | 420-449 aa |
| Gene ID | 150572 |
|---|---|
| Other Names | Histone-lysine N-methyltransferase SMYD1, SET and MYND domain-containing protein 1, SMYD1 |
| Target/Specificity | This SMYD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 420-449 amino acids from the C-terminal region of human SMYD1. |
| Dilution | FC~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SMYD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SMYD1 |
|---|---|
| Function | Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis. |
| Cellular Location | Cytoplasm. Nucleus. |
| Tissue Location | Expression seems mostly restricted to heart and skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis (By similarity).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Yang, J., et al. J. Mol. Biol. 386(4):938-950(2009)
Sims, R.J. III, et al. J. Biol. Chem. 277(29):26524-26529(2002)
Gottlieb, P.D., et al. Nat. Genet. 31(1):25-32(2002)
Srivastava, D., et al. Cold Spring Harb. Symp. Quant. Biol. 67, 121-125 (2002) :
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