CEBPE Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q15744 |
Other Accession | NP_001796.2 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 30603 Da |
Antigen Region | 203-232 aa |
Gene ID | 1053 |
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Other Names | CCAAT/enhancer-binding protein epsilon, C/EBP epsilon, CEBPE |
Target/Specificity | This CEBPE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-232 amino acids from the C-terminal region of human CEBPE. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CEBPE Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CEBPE |
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Function | Transcriptional activator (PubMed:26019275). C/EBP are DNA- binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation (PubMed:10359588). |
Cellular Location | Nucleus |
Tissue Location | Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.
References
Prasad, R.B., et al. Blood (2009) In press :
Papaemmanuil, E., et al. Nat. Genet. 41(9):1006-1010(2009)
Bedi, R., et al. Blood 113(2):317-327(2009)
Cloutier, A., et al. J. Immunol. 182(1):563-571(2009)
Matsushita, H., et al. Oncogene 27(53):6749-6760(2008)
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