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GPR27 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NS67 |
| Other Accession | Q9JJH3, O54897, NP_061844.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39818 Da |
| Antigen Region | 193-221 aa |
| Gene ID | 2850 |
|---|---|
| Other Names | Probable G-protein coupled receptor 27, Super conserved receptor expressed in brain 1, GPR27, SREB1 |
| Target/Specificity | This GPR27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 193-221 amino acids from the Central region of human GPR27. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPR27 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR27 |
|---|---|
| Synonyms | SREB1 |
| Function | Orphan receptor. Possible candidate for amine-like G-protein coupled receptor. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed as a 3.0 kb transcript in brain, ovary, testis, heart, prostate and peripheral Leukocytes. Lower levels in pancreas and small intestine. A 2.3 kb transcript was also found in peripheral Leukocytes. In brain regions, detected as a 3.0 kb transcript in all regions tested. Highest levels in the caudate nucleus, putamen, hippocampus and subthalamic nucleus. Lowest level in the cerebellum |
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Provided below are standard protocols that you may find useful for product applications.
Background
GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.[supplied by OMIM].
References
Matsumoto, M., et al. Biochem. Biophys. Res. Commun. 272(2):576-582(2000)
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