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RCL1 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RCL1 Antibody (N-term) AP1949a
    Western blot analysis of anti-RCL1 Pab (Cat. #AP1949a) in A375 cell line lysate (35ug/lane). RCL1(arrow) was detected using the purified Pab.
    detail
  • WB - RCL1 Antibody (N-term) AP1949a
    Western blot analysis of RCL1 (arrow) using rabbit polyclonal RCL1 Antibody (Cat. #AP1949a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the RCL1 gene.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9Y2P8
Other Accession Q2KHX8
Reactivity Human
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 40843 Da
Antigen Region 14-43 aa
Additional Information
Gene ID 10171
Other Names RNA 3'-terminal phosphate cyclase-like protein, RCL1, RNAC, RPC2, RPCL1, RTC2
Target/Specificity This RCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human RCL1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRCL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RCL1 (HGNC:17687)
Synonyms RNAC, RPC2, RPCL1, RTC2
Function Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome (PubMed:34516797). Does not have cyclase activity (By similarity).
Cellular Location Nucleus, nucleolus.
Citations (0)
citation

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Background

RCL1, which does not have cyclase activity, plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.

References

Billy, E., et al., EMBO J. 19(9):2115-2126 (2000).
Genschik P., et al., EMBO J. 16(10):2955-67 (1997).

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$ 182.50
$ 70.00
Cat# AP1949a
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