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CLIC2 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O15247 |
| Other Accession | Q5M883 |
| Reactivity | Human |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28356 Da |
| Gene ID | 1193 |
|---|---|
| Other Names | Chloride intracellular channel protein 2, XAP121, CLIC2 |
| Target/Specificity | This CLIC2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 105-137 amino acids from the Central region of human CLIC2. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CLIC2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLIC2 {ECO:0000303|PubMed:9339381, ECO:0000312|HGNC:HGNC:2063} |
|---|---|
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Displays weak glutathione peroxidase activity (Probable) (PubMed:25581026). Can insert into membranes and form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. |
| Cellular Location | Cytoplasm. Membrane; Single-pass membrane protein. Note=Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain |
| Tissue Location | Expressed in adult and fetal brain, heart, skeletal muscle, liver, lung, and spleen. Detected in adult stomach and testis Expressed in fetal thymus and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.
References
Heiss N.S.,et al.Genomics 45:224-228(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ross M.T.,et al.Nature 434:325-337(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Fan L.,et al.FEBS Lett. 540:77-80(2003).
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