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> home > Products > Primary Antibodies > Antibody Collections > Apoptosis signaling > BCL2L10 Antibody (Center)
BCL2L10 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IF, FC, E |
|---|---|
| Primary Accession | Q9HD36 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 23204 Da |
| Gene ID | 10017 |
|---|---|
| Other Names | Bcl-2-like protein 10, Bcl2-L-10, Anti-apoptotic protein NrH, Apoptosis regulator Bcl-B, BCL2L10, BCLB |
| Target/Specificity | This BCL2L10 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 89-123 amino acids from the Central region of human BCL2L10. |
| Dilution | IF~~1:25 WB~~1:2000 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BCL2L10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BCL2L10 {ECO:0000303|PubMed:17532299} |
|---|---|
| Function | Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (PubMed:11278245, PubMed:11689480). Increases binding of AHCYL1/IRBIT to ITPR1 (PubMed:27995898). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (PubMed:27995898). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2 (By similarity). |
| Cellular Location | Mitochondrion. Nucleus membrane. Endoplasmic reticulum. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9Z0F3}. Note=Localizes to mitochondria-associated endoplasmic reticulum membranes (MAMs) (PubMed:27995898). Localization to MAMs is greatly reduced under apoptotic stress conditions (PubMed:27995898) |
| Tissue Location | Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.
References
Zhang H.,et al.Hum. Mol. Genet. 10:2329-2339(2001).
Ke N.,et al.J. Biol. Chem. 276:12481-12484(2001).
Aouacheria A.,et al.Oncogene 20:5846-5855(2001).
Zody M.C.,et al.Nature 440:671-675(2006).
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$ 192.50
$ 75.00
Cat# AP22305c
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