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EMR3 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q9BY15 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 70 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human EMR3 |
| Epitope Specificity | 31-130/652 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. EMR3 subunit alpha: Secreted, extracellular space. Note: A soluble form is also detected. |
| SIMILARITY | Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.Contains 2 EGF-like domains.Contains 1 GPS domain. |
| SUBUNIT | Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit) (By similarity). |
| Post-translational modifications | Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. [provided by RefSeq, Jul 2008] |
| Gene ID | 84658 |
|---|---|
| Other Names | Adhesion G protein-coupled receptor E3, EGF-like module receptor 3, EGF-like module-containing mucin-like hormone receptor-like 3, ADGRE3 (HGNC:23647), EMR3 |
| Target/Specificity | Displays a predominantly leukocyte-restricted expression, with highest levels in neutrophils, monocytes and macrophages. |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | ADGRE3 (HGNC:23647) |
|---|---|
| Synonyms | EMR3 |
| Function | Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes- derived macrophages and activated neutrophils. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Displays a predominantly leukocyte-restricted expression, with highest levels in neutrophils, monocytes and macrophages. |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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$ 385.00
Cat# AP55635
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