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B4GALT6 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, IHC-F, IF, ICC |
|---|---|
| Primary Accession | Q9UBX8 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 45 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human B4GALT6 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Golgi apparatus |
| SIMILARITY | Belongs to the glycosyltransferase 7 family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Jul 2008] |
| Gene ID | 9331 |
|---|---|
| Other Names | Beta-1, 4-galactosyltransferase 6, Beta-1, 4-GalTase 6, Beta4Gal-T6, b4Gal-T6, 2.4.1.-, Glucosylceramide beta-1, 4-galactosyltransferase, 2.4.1.274, Lactosylceramide synthase, LacCer synthase, UDP-Gal:beta-GlcNAc beta-1, 4-galactosyltransferase 6, UDP-Gal:glucosylceramide beta-1, 4-galactosyltransferase, UDP-galactose:beta-N-acetylglucosamine beta-1, 4-galactosyltransferase 6, B4GALT6 (HGNC:929) |
| Target/Specificity | High expression in brain and adrenal gland, lower in liver, lung, colon and peripheral white blood cells. |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | B4GALT6 (HGNC:929) |
|---|---|
| Function | Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:1551920, PubMed:24498430, PubMed:3099851). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). |
| Cellular Location | Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P15291}; Single-pass type II membrane protein Note=Trans cisternae of Golgi stack. {ECO:0000250|UniProtKB:P15291} |
| Tissue Location | High expression in brain and adrenal gland, lower in liver, lung, colon and peripheral white blood cells |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP58010
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