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Anti-XRN2 Antibody
Rabbit polyclonal antibody to XRN2
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Application 
| WB, IHC |
|---|---|
| Primary Accession | Q9H0D6 |
| Other Accession | Q9DBR1 |
| Reactivity | Human, Mouse, Zebrafish, Monkey, Chicken, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 108582 Da |
| Gene ID | 22803 |
|---|---|
| Other Names | 5'-3' exoribonuclease 2; DHM1-like protein; DHP protein |
| Target/Specificity | Recognizes endogenous levels of XRN2 protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/100 - 1/200) IH~~WB (1/500 - 1/1000), IH (1/100 - 1/200) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | XRN2 |
|---|---|
| Function | Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G- rich pause sites (PubMed:21700224). |
| Cellular Location | Nucleus, nucleolus. |
| Tissue Location | Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas Isoform 2 is expressed predominantly in peripheral blood leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human XRN2. The exact sequence is proprietary.
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