Anti-ZAR1 Antibody
Rabbit polyclonal antibody to ZAR1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q86SH2 |
Other Accession | Q80SU3 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 45873 Da |
Gene ID | 326340 |
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Other Names | Zygote arrest protein 1; Oocyte-specific maternal effect factor |
Target/Specificity | Recognizes endogenous levels of ZAR1 protein. |
Dilution | WB~~WB (1/500 - 1/1000) |
Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | ZAR1 {ECO:0000303|PubMed:12539046, ECO:0000312|HGNC:HGNC:20436} |
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Function | mRNA-binding protein that mediates formation of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes. MARDO assembly around mitochondria is directed by an increase in mitochondrial membrane potential during oocyte growth. Promotes formation of MARDO phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to maternal mRNAs. Binds to the 3'-UTR of maternal mRNAs. Maternal mRNAs stored in the MARDO are translationally repressed. Essential for female fertility and oocyte-to-embryo transition by coordinating maternal mRNA storage, translation and degradation. |
Cellular Location | Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q80SU3}. Cytoplasm {ECO:0000250|UniProtKB:Q80SU3}. Note=Specifically localizes to MARDO (mitochondria-associated ribonucleoprotein domain), a mitochondria- associated membraneless compartment that stores mRNAs in oocytes {ECO:0000250|UniProtKB:Q80SU3} |
Tissue Location | Ovary and testis.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human ZAR1. The exact sequence is proprietary.
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