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PHAPI2 Rabbit mAb
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- BACKGROUND
Application 
| WB, IHC-P, IHC-F, ICC |
|---|---|
| Primary Accession | Q92688 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 28788 Da |
| Gene ID | 10541 |
|---|---|
| Other Names | ANP32B |
| Dilution | WB~~1/500-1/1000 IHC-P~~N/A IHC-F~~N/A ICC~~N/A |
| Format | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Name | ANP32B |
|---|---|
| Synonyms | APRIL, PHAPI2 |
| Function | Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). |
| Cellular Location | [Isoform 1]: Nucleus. Cytoplasm Note=Accumulates in the nuclei at the S phase. |
| Tissue Location | Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 385.00
Cat# AP75903
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