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POLDIP2 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y2S7 |
| Other Accession | Q91VA6 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42033 Da |
| Antigen Region | 105-133 aa |
| Gene ID | 26073 |
|---|---|
| Other Names | Polymerase delta-interacting protein 2, 38 kDa DNA polymerase delta interaction protein, p38, POLDIP2, PDIP38, POLD4 |
| Target/Specificity | This POLDIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-133 amino acids from the Central region of human POLDIP2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | POLDIP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | POLDIP2 {ECO:0000303|PubMed:26984527, ECO:0000312|HGNC:HGNC:23781} |
|---|---|
| Function | Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites (PubMed:24191025). May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1) (PubMed:24191025, PubMed:26984527). |
| Cellular Location | Mitochondrion matrix. Nucleus Note=Mainly localizes to the mitochondrial matrix; a small fraction localizes in the nucleus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
POLDIP2 is a protein that interacts with the DNA polymerase delta p50 subunit. This protein also interacts with proliferating cell nuclear antigen. Some transcripts of POLDIP2 gene overlap in a tail-to-tail orientation with the gene for tumor necrosis factor, alpha-induced protein 1 (TNFAIP1).
References
Cheng,X., Kanki,T. J. Biochem. 138 (6), 673-678 (2005)
Liu,L., Rodriguez-Belmonte,E.M. J. Biol. Chem. 278 (12), 10041-10047 (2003)
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