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XDH Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | P47989 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 146424 Da |
| Antigen Region | 206-234 aa |
| Gene ID | 7498 |
|---|---|
| Other Names | Xanthine dehydrogenase/oxidase, Xanthine dehydrogenase, XD, Xanthine oxidase, XO, Xanthine oxidoreductase, XOR, XDH, XDHA |
| Target/Specificity | This XDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-234 amino acids from the N-terminal region of human XDH. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | XDH Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | XDH |
|---|---|
| Synonyms | XDHA |
| Function | Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). |
| Cellular Location | Cytoplasm. Peroxisome. Secreted |
| Tissue Location | Detected in milk (at protein level). {ECO:0000269|Ref.12} |
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Provided below are standard protocols that you may find useful for product applications.
Background
XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.
References
Ross,C.J., et.al., Nat. Genet. 41 (12), 1345-1349 (2009)
Taibi,G., et.al., J. Cell. Biochem. 108 (3), 688-692 (2009)
Spiekermann,S., et.al., Eur. Respir. J. 34 (1), 276 (2009)
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