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ITPKC Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q96DU7 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 75207 Da |
| Antigen Region | 89-117 aa |
| Gene ID | 80271 |
|---|---|
| Other Names | Inositol-trisphosphate 3-kinase C, Inositol 1, 5-trisphosphate 3-kinase C, IP3 3-kinase C, IP3K C, InsP 3-kinase C, ITPKC, IP3KC |
| Target/Specificity | This ITPKC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-117 amino acids from the N-terminal region of human ITPKC. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ITPKC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ITPKC (HGNC:14897) |
|---|---|
| Synonyms | IP3KC |
| Function | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5- trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (PubMed:11085927, PubMed:12747803). Can phosphorylate inositol 2,4,5- triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity). |
| Cellular Location | Nucleus. Cytoplasm. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity {ECO:0000250|UniProtKB:Q80ZG2} |
| Tissue Location | Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
ITPKC encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.
References
Chi,H. Hum. Mol. Genet. 19 (6), 1147-1151 (2010)
Onouchi,Y. Nat. Genet. 40 (1), 35-42 (2008)
Nalaskowski,M.M. Biol. Chem. 387 (5), 583-593 (2006)
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