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ARHGEF11 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant ARHGEF11.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O15085 |
| Other Accession | BC057394 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2F4 |
| Calculated MW | 167704 Da |
| Gene ID | 9826 |
|---|---|
| Other Names | Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF, ARHGEF11, KIAA0380 |
| Target/Specificity | ARHGEF11 (AAH57394, 651 a.a. ~ 750 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ARHGEF11 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.
References
Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms. Akiyama K, et al. J Hum Genet, 2010 Jul 8. PMID 20613766.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.PYK2/PDZ-RhoGEF links Ca2+ signaling to RhoA. Ying Z, et al. Arterioscler Thromb Vasc Biol, 2009 Oct. PMID 19759375.The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF. Banerjee J, et al. Biochemistry, 2009 Aug 25. PMID 19618964.On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF. Zheng M, et al. BMC Struct Biol, 2009 May 21. PMID 19460155.
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