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MTAP Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant MTAP.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF |
|---|---|
| Primary Accession | Q13126 |
| Other Accession | BC018625 |
| Reactivity | Human, Mouse, Rat |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2G4 |
| Calculated MW | 31236 Da |
| Gene ID | 4507 |
|---|---|
| Other Names | S-methyl-5'-thioadenosine phosphorylase {ECO:0000255|HAMAP-Rule:MF_03155}, 24228 {ECO:0000255|HAMAP-Rule:MF_03155}, 5'-methylthioadenosine phosphorylase {ECO:0000255|HAMAP-Rule:MF_03155}, MTA phosphorylase {ECO:0000255|HAMAP-Rule:MF_03155}, MTAP {ECO:0000255|HAMAP-Rule:MF_03155}, MTAPase {ECO:0000255|HAMAP-Rule:MF_03155}, MTAP {ECO:0000255|HAMAP-Rule:MF_03155}, MSAP |
| Target/Specificity | MTAP (AAH18625, 1 a.a. ~ 154 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | MTAP Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.
References
1.Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression.Rose AE, Poliseno L, Wang J, Clark M, Pearlman A, Wang G, Vega Y Saenz de Miera EC, Medicherla R, Christos PJ, Shapiro RL, Pavlick AC, Darvishian F, Zavadil J, Polsky D, Hernando E, Ostrer H, Osman I.Cancer Res. 2011 Feb 22. [Epub ahead of print]
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