NR2E1 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant NR2E1.
|Calculated MW||42589 Da|
|Other Names||Nuclear receptor subfamily 2 group E member 1, Nuclear receptor TLX, Protein tailless homolog, Tll, hTll, NR2E1, TLX|
|Target/Specificity||NR2E1 (NP_003260, 249 a.a. ~ 342 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||NR2E1 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation. Liu HK, et al. Genes Dev, 2010 Apr 1. PMID 20360385.Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX. Iwahara N, et al. Biochem Biophys Res Commun, 2009 Sep 4. PMID 19555662.A common variant in DRD3 receptor is associated with autism spectrum disorder. de Krom M, et al. Biol Psychiatry, 2009 Apr 1. PMID 19058789.Transrepressive function of TLX requires the histone demethylase LSD1. Yokoyama A, et al. Mol Cell Biol, 2008 Jun. PMID 18391013.Initial association of NR2E1 with bipolar disorder and identification of candidate mutations in bipolar disorder, schizophrenia, and aggression through resequencing. Kumar RA, et al. Am J Med Genet B Neuropsychiatr Genet, 2008 Sep 5. PMID 18205168.
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