SYT2 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8N9I0 |
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Clone Names | 100427313 |
Gene ID | 127833 |
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Other Names | Synaptotagmin-2, Synaptotagmin II, SytII, SYT2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP13771c was selected from the Center region of SYT2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SYT2 (HGNC:11510) |
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Function | Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). |
Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P29101}; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P29101}. Cytoplasm {ECO:0000250|UniProtKB:P29101} |
Tissue Location | Expressed at the neuromuscular junction (PubMed:33659639). Expressed in melanocytes (PubMed:23999003) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Synaptotagmins, like SYT2, are integral membrane proteinsof synaptic vesicles thought to serve as Ca(2+) sensors in theprocess of vesicular trafficking and exocytosis (Hilbush andMorgan, 1994 [PubMed 8058779]).
References
Young, S.M. Jr., et al. Neuron 63(4):482-496(2009)Han, C., et al. J. Immunol. 182(5):2986-2996(2009)Laohavisit, A., et al. Plant Cell 21(2):479-493(2009)Shi, J., et al. Biochem. Biophys. Res. Commun. 374(2):331-335(2008)Lee, B.H., et al. Mol. Cell 15(5):741-751(2004)
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