CCDC50 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8IVM0 |
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Clone Names | 100517180 |
Gene ID | 152137 |
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Other Names | Coiled-coil domain-containing protein 50, Protein Ymer, CCDC50, C3orf6 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CCDC50 |
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Synonyms | C3orf6 |
Function | Involved in EGFR signaling. |
Cellular Location | Cytoplasm. Note=Associated with microtubules of the cytoskeleton and mitotic apparatus. |
Tissue Location | Isoform 1 and isoform 2 are coexpressed in placenta, liver, lung, kidney and pancreas. Only isoform 1 is detected in skeletal muscle, brain and heart. |
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Background
This gene encodes a soluble, cytoplasmic,tyrosine-phosphorylated protein with multiple ubiquitin-interactingdomains. Mutations in this gene cause nonsyndromic, postlingual,progressive sensorineural DFNA44 hearing loss. In mouse, theprotein is expressed in the inner ear during development andpostnatal maturation and associates with microtubule-basedstructures. This protein may also function as a negative regulatorof NF-kB signaling and as an effector of epidermal growth factor(EGF)-mediated cell signaling. Alternative splicing results inmultiple transcript variants encoding distinct isoforms. [providedby RefSeq].
References
Farfsing, A., et al. Leukemia 23(11):2018-2026(2009)Kameda, H., et al. Biochem. Biophys. Res. Commun. 378(4):744-749(2009)Bohgaki, M., et al. Biochim. Biophys. Acta 1783(5):826-837(2008)Modamio-Hoybjor, S., et al. Am. J. Hum. Genet. 80(6):1076-1089(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)
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