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TULP3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O75386 |
|---|---|
| Clone Names | 110808028 |
| Gene ID | 7289 |
|---|---|
| Other Names | Tubby-related protein 3, Tubby-like protein 3, TULP3, TUBL3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TULP3 (HGNC:12425) |
|---|---|
| Synonyms | TUBL3 |
| Function | Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT- A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes. |
| Cellular Location | Nucleus. Cell membrane. Cell projection, cilium. Cytoplasm. Secreted. Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha |
| Tissue Location | Expressed at high levels in testis, ovaries, thyroid, and spinal chord. |
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Background
This gene encodes a member of the tubby gene family ofbipartite transcription factors. Members of this family have beenidentified in plants, vertebrates, and invertebrates, and theyshare a conserved N-terminal transcription activation region and aconserved C-terminal DNA and phosphatidylinositol-phosphate bindingregion. The encoded protein binds to phosphoinositides in theplasma membrane via its C-terminal region and probably functions asa membrane-bound transcription regulator that translocates to thenucleus in response to phosphoinositide hydrolysis, for instance,induced by G-protein-coupled-receptor signaling. It plays animportant role in neuronal development and function. Two transcriptvariants encoding distinct isoforms have been identified for thisgene.
References
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Ikeda, A., et al. J. Cell. Sci. 115 (PT 1), 9-14 (2002) :Santagata, S., et al. Science 292(5524):2041-2050(2001)Ikeda, S., et al. Invest. Ophthalmol. Vis. Sci. 40(11):2706-2712(1999)Nishina, P.M., et al. Genomics 54(2):215-220(1998)
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