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RNF6 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9Y252
Clone Names 100603226
Additional Information
Gene ID 6049
Other Names E3 ubiquitin-protein ligase RNF6, 632-, RNF6, SPG2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF6
Synonyms SPG2
Function E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys- 27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
Cellular Location Nucleus. Cytoplasm. Cell projection, axon Nucleus, PML body. Note=Localizes to the PML nuclear bodies in Sertoli cells.
Tissue Location Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
Research Areas
Citations (0)

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The protein encoded by this gene contains a RING-H2 fingermotif. Deletions and mutations in this gene were detected inesophageal squamous cell carcinoma (ESCC), suggesting that thisprotein may be a potential tumor suppressor. Studies of the mousecounterpart suggested a role of this protein in the transcriptionregulation that controls germinal differentiation. Multiplealternatively spliced transcript variants encoding the same proteinare observed.


Xu, K., et al. Cancer Cell 15(4):270-282(2009)Zhu, L., et al. Sci. China, C, Life Sci. 51(4):302-307(2008)Tursun, B., et al. Genes Dev. 19(19):2307-2319(2005)Lo, H.S., et al. Cancer Res. 62(15):4191-4193(2002)Lopez, P., et al. Mol. Cell. Biol. 22(10):3488-3496(2002)

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$ 277.78
Cat# BP19165b
Availability: 2 weeks
Bulk Size

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