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RNF6 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y252 |
|---|---|
| Clone Names | 100603226 |
| Gene ID | 6049 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase RNF6, 632-, RNF6, SPG2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RNF6 {ECO:0000303|PubMed:10331950, ECO:0000312|HGNC:HGNC:10069} |
|---|---|
| Function | E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation (By similarity). Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover (By similarity). Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity (PubMed:19345326). May also bind DNA and function as a transcriptional regulator (By similarity). Mediates polyubiquitination of QKI in macrophages, leading to its degradation (By similarity). |
| Cellular Location | Nucleus. Cytoplasm. Cell projection, axon {ECO:0000250|UniProtKB:Q9DBU5}. Nucleus, PML body {ECO:0000250|UniProtKB:Q9DBU5}. Note=Localizes to the PML nuclear bodies in Sertoli cells. {ECO:0000250|UniProtKB:Q9DBU5} |
| Tissue Location | Weakly expressed in peripheral blood, spleen, prostate, testis and ovary (PubMed:19345326). According to a report, it is preferentially expressed in testis and ovary and hardly detected in other tissues (PubMed:18368307). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene contains a RING-H2 fingermotif. Deletions and mutations in this gene were detected inesophageal squamous cell carcinoma (ESCC), suggesting that thisprotein may be a potential tumor suppressor. Studies of the mousecounterpart suggested a role of this protein in the transcriptionregulation that controls germinal differentiation. Multiplealternatively spliced transcript variants encoding the same proteinare observed.
References
Xu, K., et al. Cancer Cell 15(4):270-282(2009)Zhu, L., et al. Sci. China, C, Life Sci. 51(4):302-307(2008)Tursun, B., et al. Genes Dev. 19(19):2307-2319(2005)Lo, H.S., et al. Cancer Res. 62(15):4191-4193(2002)Lopez, P., et al. Mol. Cell. Biol. 22(10):3488-3496(2002)
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