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AQP3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92482 |
|---|---|
| Clone Names | 100623018 |
| Gene ID | 360 |
|---|---|
| Other Names | Aquaporin-3, AQP-3, Aquaglyceroporin-3, AQP3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | AQP3 {ECO:0000303|PubMed:7558005, ECO:0000312|HGNC:HGNC:636} |
|---|---|
| Function | Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:12239222, PubMed:30420639). Could also be permeable to urea (By similarity). Also participates in cell permeability to H2O2 and H2O2- mediated signaling (PubMed:20724658). In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair (By similarity). In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14520}. Basolateral cell membrane {ECO:0000250|UniProtKB:P47862}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14520} |
| Tissue Location | Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level |
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Provided below are standard protocols that you may find useful for product applications.
Background
Aquaporin 3 is a water channel protein. Aquaporins are afamily of small integral membrane proteins related to the majorintrinsic protein (MIP or AQP0). Aquaporin 3 is localized at thebasal lateral membranes of collecting duct cells in the kidney. Inaddition to its water channel function, aquaporin 3 has been foundto facilitate the transport of nonionic small solutes such as ureaand glycerol, but to a smaller degree. It has been suggested thatwater channels can be functionally heterogeneous and possess waterand solute permeation mechanisms.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kim, N.H., et al. J. Invest. Dermatol. 130(9):2231-2239(2010)Ji, C., et al. Int. J. Mol. Med. 26(2):257-263(2010)Melis, M., et al. Dis. Colon Rectum 53(6):936-943(2010)Shen, L., et al. Biomed. Pharmacother. 64(5):313-318(2010)
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